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Aminophylline Tablets
 This product requires a valid prescription
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Aminophylline is a type of medicine called a xanthine bronchodilator. It is used to open the airways and aid breathing in lung conditions such as asthma and chronic bronchitis. Once in the body aminophylline is converted to another medicine called theophylline. Theophylline causes the muscles surrounding the airways to relax, by a mechanism that is not fully understood. This allows the airways in the lungs to open. In conditions where the airways tighten, such as asthma, it is difficult for air to get in and out of the lungs. By opening the airways, aminophylline makes it easier to breathe in these conditions.
Aminophylline should not be used if you are allergic to one or any of its ingredients. Please inform your doctor or pharmacist if you have previously experienced such an allergy.
If you feel you have experienced an allergic reaction, stop using Aminophylline and inform your doctor or pharmacist immediately.
The safety of Aminophylline during pregnancy has not been established, but it has been in use for many years with no apparant ill consequence. However, use during the third trimester may be associated with irritability in the baby. Aminophylline should be used during pregnancy only when the benefits outweigh any possible risks to the foetus. Discuss this with your doctor.
Aminophylline passes into breast milk and may be asociated with irritability in the breast fed infant. Seek medical advice from your doctor before using this medicine during breastfeeding.
Aminophylline side effects can affect individual people in different ways. The following are some of the Aminophylline side effects that are known to be associated with Aminophylline. Because a Aminophylline side effect is stated here, it does not mean that all people using this medicine will experience that or any side effect.
Faster than normal heart beat (tachycardia)
Restlessness
Awareness of your heart beat (heart palpitations)
Low blood potassium level (hypokalaemia)
Abdominal discomfort
Headache
Nausea
Difficulty in sleeping (insomnia)
The Aminophylline side effects listed above may not include all of the side effects reported by the drug's manufacturer.
For more information about any other possible risks associated with Aminophylline, please read the information provided with the medicine or consult your doctor or pharmacist.
Children must not take medicines containing ephedrine (present in many cough and cold remedies) while taking aminophylline.
The following medicines may increase the blood levels of aminophylline:
- aciclovir
- allopurinol
- calcium channel blockers, eg verapamil, nifedipine
- methotrexate
- isoniazid
- flu vaccine
- quinolone type antibiotics, eg ciprofloxacin, enoxacin, norfloxacin
- macrolide type antibiotics, eg erythromycin, clarithromycin
- cimetidine
- oral contraceptives
- disulfuram
- fluvoxamine
- interferons
- mexiletine
- tiabendazole
- ticlopidine
- propafenone
- propranolol.
Your doctor may reduce your aminophylline dose if you are taking any of these.
The following medicines may decrease the blood levels of aminophylline:
- aminoglutethimide
- barbiturates
- moracizine
- St John's wort
- sulphinpyrazone
- antiepileptic medicines, such as phenytoin, carbamazepine
- rifampicin
- rifabutin
- ritonavir.
Your doctor may increase your aminophylline dose if you are taking any of these medicines.
Aminophylline may decrease the blood levels of the following medicines, which may reduce their effects:
- lithium
- phenytoin
- carbamazepine.
Aminophylline should not normally be taken with beta-blockers such as propranolol, as these decrease the effectiveness of aminophylline in keeping the airways open.
There may be an increased risk of bleeding if this medicine is taken with lomustine.
Aminophylline may oppose the effects of the following medicines:
- benzodiazepines, eg diazepam
- adenosine.
The level of thyroid hormones in the body affects the way the body handles aminophylline. If you have high thyroid hormone levels and start treatment to lower them, eg with medicines such as carbimazole, propylthiouracil or radioactive iodine, your doctor may decrease your aminophylline dose. If you have low thyroid hormone levels and start treatment with thyroxine, your doctor may increase your aminophylline dose.
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