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Oxsoralen (methoxsalen lotion)

Manufactured by: ICN Pharmaceuticals

This product requires a valid prescription

	Type	Strength		Quantity		Price (USD)
	Brand			30ml Lotion		$126.49	BUY

BUY CHEAP OXSORALEN-ULTRA FROM CANADA!

Oxsoralen (methoxsalen) is for the treatment of severe psoriasis. Certain skin problems present a unique set of challenges that can evoke a wide range of personal responses. Among the many diseases are psoriasis, producing red and scaly patches; vitiligo, a disease in which skin color is lost; and mycosis fungoides, a type of lymphoma. Methoxsalen, the active ingredient in Oxsoralen-Ultra, belongs to the group of compounds called psoralens. It is used along with ultraviolet light (found in sunlight and some special lamps) in a treatment call PUVA (Psoralen plus UVA) to treat psoriasis and vitiligo. Methoxsalen is also used together with ultraviolet light in photopheresis, used to treat the white blood cells associated with mycosis fungoides.

PUVA is an acronym for Psoralen plus UVA light and is a special type of phototherapy that combines the use of the drug Oxsoralen Ultra (methoxsalen) with exposure of the skin to UVA (ultraviolet A) light. Oxsoralen Ultra (methoxsalen) capsules make the skin more sensitive to light.

Ultraviolet A light is composed of the longest wavelengths in the ultraviolet spectrum. However, UVA light does have the property of being able to react with light-activated chemicals in the skin, or so-called photosensitizing agents. Psoralens, such as those present in Oxsoralen Ultra (methoxsalen), are photosensitizing compounds that are activated by UVA light. If they are present in the skin at the time of exposure to UVA light, they greatly increase the effect of the light on the skin. This increased sensitivity is the key to the beneficial effect of PUVA therapy.

PUVA is an effective therapy for severe recalcitrant psoriasis. Another benefit of PUVA therapy is that it tends to induce long-term remissions in psoriasis.

Your doctor will prescribe the appropriate number of Oxsoralen-Ultra (Methoxsalen Capsules, USP, 10mg) capsules to take before a PUVA treatment. Be sure to always take the exact dosage prescribed. Swallow the capsules with low-fat food or milk 1.5 to 2 hours before your appointment.

The PUVA treatment should only take place in your doctor's office, where you will stand in a special lighted area or booth for a short period of time. (A hand-held light unit may be used for smaller body areas.) In the PUVA treatment area, you will be surrounded by light bulbs that deliver special UVA light. You will be unclothed or partially clothed (depending on the size of the area to be treated) and you must wear UVA protective goggles, which will be provided by your doctor. Male genitalia must be shielded unless the area is being treated for psoriasis. Other sensitive areas such as the face, lips and breasts may also require protection. Treatment time may last from a few seconds to over 10 minutes and may vary from one treatment to the next.

Psoriasis sufferers who have been treated unsuccessfully with conventional treatments are candidates for PUVA therapy. PUVA therapy involves the ingestion of Oxsoralen-Ultra (Methoxsalen Capsules, USP, 10mg) 1.5 to 2 hours prior to exposure to UVA light. The dose of Oxsoralen-Ultra capsules you take is held constant and is determined by your weight. The interval between taking Oxsoralen-Ultra capsules and being exposed to light is also held constant because peak levels of psoralen are usually reached in the skin between 1.5 to 2 hours after ingestion.

The variable in PUVA therapy is the dose of UVA light you are given. The initial dose is low and may be determined by your past history of sunburning and suntanning, or by testing your response to PUVA. The dose of UVA light is gradually increased in subsequent treatment as your tolerance to the treatment increases.

The dose of UVA light delivered during PUVA therapy is measured in joules per square centimeter (a measure of energy) and is translated into a given number of minutes of treatment. The output of the treatment units varies over time and different units emit different amounts of energy. Therefore, even if your dose of UVA light is constant, your treatment times may vary. Treatments will be required two to three times each week until your skin disease has cleared. Less frequent treatment is necessary to maintain a clear state. Most patients develop a tan or deepening of their normal skin pigmentation from PUVA therapy. The tanning may be uneven at first, with skin color lighter in areas affected by psoriasis. Some patients also develop freckles — particularly dark freckles — in areas affected by psoriasis. Burning from light treatment is a potential serious side effect of PUVA therapy. Regardless of how carefully light treatment is administered, some redness is likely to occur, especially at the beginning of therapy. If you experience any degree of redness or burning following treatment, be sure to alert your medical provider. The light dose may need to be lowered or you may need to skip a treatment. The most common side effects of PUVA therapy are:

Skin Burning. Serious burns from either UVA or sunlight (even through a window glass) can result if the recommended dosage of the drug and/or exposure schedules are exceeded.
Sunburn. Some redness is likely to occur in the skin at the beginning of PUVA therapy.
Pigmentation. Many patients observe pigmentation or tanning of their skin.
Nausea. Nausea may occur after taking the Oxsoralen-Ultra (Methoxsalen Capsules, USP, 10mg) capsules. This may be avoided or lessened by taking the medication with milk or grain-type foods such as crackers, toast or bagels, or by taking the drug just after a meal.
Itching. Itching commonly occurs as a result of light treatment. Numerous ointments are available to soothe mild itching. It is important to make your medical provider aware of any itching you have. With severe itching, it may be necessary to lower the light dose or skip a treatment. Call your medical provider before taking your capsules if itching is severe.
Dry skin. If PUVA therapy leads to dry skin, apply a moisturizing lotion while your skin is still damp after showering or bathing. If the moisturizer does not relieve your dry skin, ask your medical provider for other recommendations.
Friction blisters. Blisters are a fairly common occurrence, particularly on the hands and feet.
Ankle edema. A small number of patients develop swelling of the ankles as the first sign of phototoxicity.
Aggravation of skin disease. PUVA can sometimes aggravate and worsen the skin disease.
Increased hair growth. Hypertrichosis, or an increased growth of hair, particularly on the face, is an occasional side effect.

The total number of treatments depends on your diagnosis. In the beginning, treatments will be necessary two to three times per week. Eventually, the number decreases to a maintenance schedule or reaches a point at which you can stop completely if your skin remains clear. Your treatment must be spaced so that at least 48 hours elapse between sessions. The average course of treatment lasts approximately 12 weeks. PUVA therapy clears or dramatically improves psoriasis in over 84% of patients and can lead to extended remissions. Once your skin has cleared, you may continue PUVA therapy on a maintenance schedule of once a week, and then gradually decrease your treatments to one per month if your skin remains clear. If it is still clear after three to four months of maintenance therapy, you may discontinue PUVA therapy. If you experience a flare-up, therapy will be reinstated two to three times a week.

Long-term effects associated with PUVA therapy:

Skin cancer. Some people are at a higher risk than the normal population for developing skin cancer, including people who have had previous non-melanoma skin cancer, arsenic therapy or X-ray therapy to the skin, as well as individuals with extremely light complexions which always burn and never tan. In general, these patients are not considered for PUVA therapy unless strong extenuating circumstances exist in favor of it. For all other patients, there may be a minimally higher incidence of skin cancer. Because it is impossible to know exactly how much light a patient needs in order to produce a skin cancer, your skin should frequently be examined for abnormal growths throughout your PUVA therapy.
Cataracts. Animal studies show that cataracts may be produced as a result of excess PUVA therapy when no eye protection is used. If a patient undergoing PUVA therapy does not carefully protect his or her eyes by wearing appropriate protective sunglasses, there may be a risk of developing cataracts. To date, very few eye problems have been experienced with our patients since most are conscientious about following the simple instructions for eye protection during and following PUVA therapy. Pre-treatment eye exams and yearly followup exams are also required.

Shielding the eyes after Oxsoralen-Ultra capsule ingestion and for 24 hours thereafter during daylight hours is an absolute requirement. Make sure you wear special wraparound sunglasses that absorb ultraviolet light or block it entirely. These special sunglasses should be worn when you are outdoors, riding in a car or sitting near a window. Do not attempt to drive in dim light while wearing dark glasses. On non-treatment days, you should routinely wear either plastic wraparound or UVA-blocking sunglasses. Prescription sunglasses should be checked for their ability to block UVA light. This check may be performed at the phototherapy unit by your phototherapist. Do not allow your skin or lips to be exposed to sunlight for eight hours after treatment. In addition, do not expose your skin to either sunlight or sunlamps within 24 hours of treatment. It is advisable to wear protective clothing (i.e., hat, gloves, long sleeves) to cover as much of your body as possible, and to use a UVA-blocking sunscreen product with a sun protection factor (SPF) of at least 15. You must not sunbathe for 24 hours before and after PUVA therapy.

Drug Overview
Effects - How it works in the body
Side effects
Interactions
Counterindications
Similar drugs of Oxsoralen
Major drug Manufacturers
From where can one get Oxsoralen?
Why to buy Oxsoralen drug from Canada?

Drug Overview

Oxsoralen belongs to the group of medicines called psoralens drugs which are also known as photosensitizer drugs, commonly used for the treatment of the symptoms of psoriasis and vitiligo. To be effective, this medication is used in conjunction with ultraviolet (UVA) light therapy. It is used along with ultraviolet light (found in sunlight and some special lamps) in a treatment call PUVA (Psoralen plus UVA) to treat psoriasis and vitiligo. Oxsoralen are also used for the treatment of disease in which skin color is lost, and psoriasis, a skin condition associated with red and scaly patches. Oxsoralen is used to treat the skin conditions vitiligo, psoriasis, and atopic dermatitis. For vitiligo, a skin condition where the skin loses its color in irregular patches. Oxsoralen works by restoring color to the affected areas.

Oxsoralen always takes under doctor’s guidance. The recommended doses of Oxsoralen will be different for different patients, according to the requirements of each patient; you continue to take it once or twice a day, with a meal and a full glass of water, for as long as your doctor prescribes, even if you do not feel an immediate benefit. Your doctor will start you on a low dose of Oxsoralen and gradually increase your dose. If you can not tolerate the recommended dosage, your doctor can prescribe a dose that sufficient for you. Do not take more or less of Oxsoralen Tablets or take it more often than prescribed by your doctor. Oxsoralen is also available in generic form known as Oxsoralen. Oxsoralen is being manufactured by ICN Pharmaceuticals and available in 10mg Capsules. Oxsoralen may also be used for relieve other conditions that determined by your doctor or consultant.

Effects - How it works in the body

Oxsoralen belongs to the group of medicines called psoralens drugs which are also known as photosensitizer drugs, commonly used for the treatment of the symptoms of psoriasis and vitiligo. To be effective, this medication is used in conjunction with ultraviolet (UVA) light therapy. It is used along with ultraviolet light (found in sunlight and some special lamps) in a treatment call PUVA (Psoralen plus UVA) to treat psoriasis and vitiligo. Oxsoralen are also used for the treatment of disease in which skin color is lost, and psoriasis, a skin condition associated with red and scaly patches. Oxsoralen is used to treat the skin conditions vitiligo, psoriasis, and atopic dermatitis. For vitiligo, a skin condition where the skin loses its colour in irregular patches. Oxsoralen works by restoring color to the affected areas. Oxsoralen is also used together with ultraviolet light in photopheresis, used to treat the white blood cells associated with mycosis fungoides. Oxsoralen capsules make the skin more sensitive to light.

Side effects

Possible side effects during the uses of Oxsoralen:

Allergies
Tiredness
Weakness
Dry mouth
Blistering and peeling of skin
Reddened or sore skin
Swelling (especially of feet or lower legs)
Itching of skin
Nausea
Dizziness
Headache
Mental depression
Nervousness
Trouble in sleeping
Upset stomach
Changes in appetite
Constipation
Difficulty urinating
Blurred vision
Irregular heartbeat
Severe skin rash
Weight gain or loss
Unusual tiredness or weakness
Yellow eyes or skin

Interactions

Although certain medicines should not be used together at all, so its your responsibilities that tell your doctor or health care professional about all other medicines you are taking, including non-prescription medicines, nutritional supplements, or herbal products. Also you tell your doctor or health care professional if you are a frequent user of drinks with caffeine or alcohol, if you smoke, or addicted to illegal drugs. These may affect the working mechanism of Oxsoralen. In these cases, your doctor may change the dose or teach precautions may be necessary. Therefore when you are taking Oxsoralen, it is most important that your doctor or health care professional know if you are taking any of the prescription or non-prescription other drugs as:

Alchol
Griseofulvin
Medicines which used for the treatment of infections including sulfa or tetracycline antibiotics
Medicines which used for the treatment of mental problems or psychotic disturbances
Several types of water pills (diuretics)
Vitamin A and vitamin A-like medicines and creams such as Accutane, Solage
Retin-A or Differin
Vitamin E

Counterindications

You shouldn’t use this medicine without consultation of doctor if you have an allergy to Oxsoralen or any other ingredients of this medicine.

You shouldn’t use Oxsoralen without consultation of doctor if you are suffering to the problem of Brain disease.

You shouldn’t use Oxsoralen without consultation of doctor if you are suffering to the Liver problems.

You shouldn’t use Oxsoralen without consultation of doctor if you are suffering to the problems of kidney disease.

You shouldn’t use Oxsoralen without consultation of doctor if you are suffering to the Heart or blood vessel disease.

You shouldn’t use Oxsoralen without consultation of doctor if you are suffering to the problems of porphyria.

You shouldn’t use Oxsoralen without consultation of doctor if you are suffering to the problems of skin cancer.

You shouldn’t use Oxsoralen without consultation of doctor if you are suffering to the problems of skin photosensitivity problems.

You shouldn’t use Oxsoralen without consultation of doctor if you are suffering to the problems of albinism.

You shouldn’t use Oxsoralen without consultation of doctor if you are pregnant or plan to be pregnant.

You shouldn’t use Oxsoralen without consultation of doctor if you are suffering to breastfeeding.

Similar drugs of Oxsoralen

Methoxsalen
8-MOP
Oxsoralen Topical
Uvadex
Ultramop (Canada)
Oxsoralen
Ultra MOP
Oxsoralen Lotion (Canada)
UltraMOP Lotion (Canada)

Major drug Manufacturers

ICN Pharmaceuticals
Valeant Pharmaceuticals
Pharmacia Biotech
Therakos, Inc.
Derma Tech
3M Pharmaceuticals
Canderm Pharmacal

From where can one get Oxsoralen?

Anyone can buy Oxsoralen from Online Canadian Pharmacy, which is available at a discounted price, 50% off, in Canada, and the best way to get Oxsoralen is by logging on to http://www.canadiandrugswholesale.com for online orders. This pharmacy provides you with drugs at cheap and affordable prices. One can order the medicine and pay through VISA, MasterCard or international money order.

Why to buy Oxsoralen drug from Canada?

It is cheaper to buy Oxsoralen from Online Canadian Pharmacy, because Canadian government regulates the prices of Oxsoralen and also because of the very common reason of exchange rate. Since, the Canadian dollar is cheaper as compared to the US Dollars, so one can buy more Oxsoralen from Canada, there by saving a lot of money.

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