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Motilium (Domperidone Tablets)
 This product requires a valid prescription
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Domperidone (Motilium™) is a drug that has, as a side effect, stimulating or increasing milk production, probably by increasing prolactin production by the pituitary gland. Prolactin is the hormone that stimulates the cells in the mother's breast to produce milk. Domperidone increases prolactin secretion indirectly, by interfering with the action of dopamine whose action is to decrease the secretion of prolactin by the pituitary gland. Domperidone is generally used for disorders of the gastrointestinal tract (gut) and has not been released in Canada for use as a stimulant for milk production. This does not mean that it cannot be prescribed for this reason, but rather that the manufacturer does not back its use for increasing milk production. However, there are several studies that show that it works to increase milk production and that it is safe. It has been used, for several years, in small infants who spit up and lose weight, but was replaced until a few years ago by cisapride (Prepulsid™) (cisapride has since been taken off the market because it can cause serious cardiac problems). Domperidone is not in the same family of medication as cisapride and has never had the cardiac side effects that cisapride does. Another, related, but older medication, metoclopramide (Maxeran™), is also known to increase milk production, but it has frequent side effects which have made its use for many nursing mothers unacceptable (fatigue, irritability, depression). Domperidone has many fewer side effects because it does not enter the brain tissue in significant amounts (does not pass the blood-brain barrier).
Domperidone must never be used as the first approach to correcting breastfeeding difficulties. Domperidone is not a cure for all things. It must not be used unless all other factors which may result in insufficient milk supply have been dealt with first.
Domperidone works particularly well to increase milk production under the following circumstances:
-It has frequently been noted that a mother who is pumping milk for a sick or premature baby in hospital has a decrease in the amount she pumps around 4 or 5 weeks after the baby is born. The reasons for this decrease are likely many, but domperidone generally brings the amount of milk pumped back to where it was or even to higher levels.
-When a mother has a decrease in milk supply, often associated with the use of birth control pills (avoid œstrogen containing birth control pills while breastfeeding), or on occasion, for no obvious reason when the baby is 3 or 4 months old, domperidone will often bring the supply back to normal.
Domperidone still works, but often less dramatically when:
-The mother is pumping for a sick or premature baby but has not managed to develop a full milk supply.
-The mother is trying to develop a full milk supply while nursing an adopted baby.
-The mother is trying to wean the baby from supplements.
The amount of domperidone that gets into the milk is so tiny that side effects of domperidone in the baby should not be expected. Certainly the amount the baby gets through the milk is a tiny percentage of what babies would get if being treated for spitting up.
The manufacturer states in its literature that chronic treatment with domperidone in rodents has resulted in increased numbers of breast tumours in the rodents. The literature goes on to state that this has never been documented in humans. Note that toxicity studies of medication usually require treatment with huge doses over periods of time involving most or all of the animal's lifetime. Note also that not breastfeeding increases the risk of breast cancer, and breast cancer risk decreases the longer you breastfeed.
Generally, we start domperidone at 20 milligrammes (two 10 mg tablets) four times a day. If taking domperidone 4 times a day is inconvenient, 30 milligrammes (three 10 mg tablets) three times a day is fine. Printouts from the pharmacy often suggest taking domperidone 30 minutes before eating, but that is because of its use for digestive intolerance. You can take the domperidone about every 6 hours, when it is convenient (there is no need to wake up to keep to a 6 hour schedule-it does not make any difference). Most mothers take the domperidone for 3 to 8 weeks. Mothers who are nursing adopted babies may have to take the drug much longer. After starting domperidone, it may take three or four days before you notice any effect, though sometimes mothers notice an effect within 24 hours. It appears to take two to three weeks to get a maximum effect, but some mothers have noted effects only after 4 or more weeks. It is reasonable to give domperidone a trial of at least 4 weeks before saying it doesn't work.
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