|
Cisapride Tablets
 This product requires a valid prescription
| |
|
Type |
Strength |
|
Quantity |
|
Price (USD) |
|
|
|
Cisapride is used to treat symptoms of nighttime heartburn in people who have not responded to other treatments.
Cisapride comes as a tablet and liquid to take by mouth. Cisapride usually is taken four times a day, 15 minutes before meals and at bedtime. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take cisapride exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor
Cisapride is only available in the United States to special patients who are signed up by their doctors. Talk to your doctor or pharmacist about whether you should be taking cisapride.Cisapride may cause serious irregular heart beats, which can lead to death. Tell your doctor if you have a family history of heart problems and if you have or have ever had irregular heart beats, heart disease, severe dehydration, vomiting, eating disorders, or kidney or lung failure. Tell your doctor about all the prescription and nonprescription medications you are taking. Do not take cisapride if you are taking bepridil (Vascor); chlorpromazine (Thorazine); clarithromycin (Biaxin); erythromycin (E.E.S., E-Mycin, Ery-Tab); fluconazole (Diflucan); fluphenazine (Prolixin); itraconazole (Sporanox); ketoconazole (Nizoral); medications for depression such as amitriptyline (Elavil), amoxapine (Asendin), clomipramine (Anafranil), desipramine (Norpramin), doxepin (Adapin, Sinequan), imipramine (Tofranil), maprotiline (Ludiomil), nefazodone (Serzone), nortriptyline (Pamelor), protriptyline (Vivactil), and trimipramine (Surmontil); medications for irregular heart beats such as amiodarone (Cordarone), disopyramide (Norpace), quinidine (Quinidex), procainamide (Procanbid, Pronestyl), and sotalol (Betapace); mesoridazine (Serentil); perphenazine (Trilafon); prochlorperazine (Compazine); promethazine (Phenergan); protease inhibitors such as indinavir (Crixivan) and ritonavir (Norvir); sertindole (Serlect); sparfloxacin (Zagam); thioridazine (Mellaril); thiothixene (Navane); trifluoperazine (Stelazine); or troleandomycin (Tao). Do not drink grapefruit juice while taking cisapride.Do not take more of cisapride or take it more often than prescibed by your doctor. Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your body's response to cisapride. If you experience either of the following symptoms, call your doctor immediately: fainting or irregular or fast heartbeats.
Avoid cisapride with interacting medicines or predisposing conditions
Cisapride should be avoided in the following circumstances:
With use of agents inhibiting metabolism by cytochrome P450 3A4: macrolide antibiotics (erythromycin, clarithromycin, etc.), azole antifungals (ketoconazole, itraconazole, fluconazole, etc), protease inhibitors (ritonavir, indinavir, etc.), nefazodone and grapefruit juice
With use of agents which may prolong the QT-interval, quinine, terfenadine, some antiarrhythmic medicines (e.g. amiodarone, quinidine, flecainide, sotolol), tricyclic antidepressants (e.g. amitriptyline) and some antipsychotic agents (phenothiazines and haloperidol)
Cisapride (Prepulsid™) causes QT-prolongation which may worsen to life-threatening torsade de pointes. The WHO database holds 159 reports of these events. Many patients were taking interacting medicines, most commonly erythromycin, fluconazole, clarithromycin and amiodarone. Excessive dose and electrolyte disturbances also featured in the cases.
In patients with a history of QT-prolongation, ventricular arrhythmia, torsade de pointes, and those with risk factors for arrhythmia, such as second or third degree atrioventricular block, clinically significant heart disease, uncorrected electrolyte disturbances, renal or respiratory failure
Before taking cisapride,
tell your doctor and pharmacist if you are allergic to cisapride or any other drugs.
in addition to the medications listed in the IMPORTANT WARNING section, tell your doctor and pharmacist what prescription and nonprescription medications you are taking, especially antianxiety medications, anticholinergics (atropine, belladonna, benztropine, dicyclomine, diphenhydramine, isopropamide, procyclidine, and scopolamine), anticoagulants ('blood thinners') such as warfarin (Coumadin), azithromycin (Zithromax), cimetidine (Tagamet), dirithromycin (Dynabac), diuretics ('water pills'), miconazole (Monistat), tranquilizers, and vitamins.
tell your doctor if you have or have ever had intestinal disorders or bleeding ulcers.
tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking cisapride, call your doctor.
you should know that this drug may make you drowsy. Do not drive a car or operate machinery until you know how this drug affects you.
remember that alcohol can add to the drowsiness caused by this drug.
|
|
|
|
