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Isoniazid Tablets
 This product requires a valid prescription
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Isoniazid is an antibiotic used to prevent and treat tuberculosis. To prevent development of resistant tuberculosis bacteria, people with tuberculosis are treated with long courses of combination drug therapy, most commonly isoniazid, rifampin, and pyrazinamide. Isoniazid is capable of causing vitamin B3 (niacin) deficiency, most likely due to its ability to interfere with cell-repair enzymes made from niacin. Significant niacin deficiency, also known as pellagra, features dermatitis, diarrhea, and dementia (impaired intellectual function). Supplementation with vitamin B6 is thought to reduce this risk, although small amounts (e.g. 10 mg daily) has been noted to be inadequate in some cases. Many antibiotics taken by mouth, including isoniazid, may kill friendly bacteria in the large intestine that produce vitamin K. Daily alcohol intake increases the risk of isoniazid-related hepatitis. Alcohol may interact with isoniazid, causing facial flushing, headache, light-headedness, nausea, breathlessness, and other symptoms. To prevent unwanted reactions, people taking isoniazid should avoid alcohol-containing products. If isoniazid upsets your stomach it should be taken with food. Antacids may help but those containing aluminum should be avoided. Tell your physician if you are on a low-sodium, low-sugar, or any other special diet before taking isoniazid. Your doctor may want you to take pyridoxine (Vitamin B6) every day to help avoid side effects. If pyridoxine is needed, it must be taken every day; do not skip doses. Isoniazid has not been shown to cause birth defects in humans or animals. Studies have shown an increased risk of fetal death in animals. Side effects that usually go away as your body adjusts to the medication and do not require medical attention unless they persist or are bothersome: nervousness; restlessness; sleep difficulties; dizziness; rapid heartbeat; flushing; headache; sweating; nausea; trembling; weakness; pink or red saliva. Side effects that should be reported to your physician as soon as possible: chest pain; irregular heartbeat. Since it may be difficult to distinguish between certain common symptoms of MS and some side effects of isoniazid, be sure to consult your health care professional if an abrupt change of this type occurs.
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